Porcine Hemagglutinating Encephalomyelitis Virus Co-Opts Multivesicular-Derived Exosomes for TransmissionArticle Published on 2023-02-282023-07-11 Journal: mBio [Category] COVID19(2023년), [키워드] Betacoronavirus Exosome innate response porcine hemagglutinating encephalomyelitis virus Transmission. [DOI] 10.1128/mbio.03054-22 PMC 바로가기
A hybrid discrete-continuum model of immune responses to SARS-CoV-2 infection in the lung alveolar region, with a focus on interferon induced innate responseArticle Published on 2022-12-212022-11-15 Journal: Journal of theoretical biology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] adaptive alveolar alveolar cells antibodies antibody antibody concentration baseline Cell cell death Cellular automaton COVID-19 develop diffusion domain Efficacy Future Gas exchange healthy human lung Immune cell immune protection immune response Immunity infected cell Infection initial Innate innate immune Innate immunity innate response Interaction interferon interferons lung alveolar maintain manuscript mechanism Model multiple mechanism outcome Pneumonia produced profiles progression Result RNA copy SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant simulations. Spread Strains submitted switching T cells the SARS-CoV-2 virus two-dimensional type I Viral load virion virions [DOI] 10.1016/j.jtbi.2022.111293 PMC 바로가기
Coordinated innate and T-cell immune responses in mild COVID-19 patients from household contacts of COVID-19 cases during the first pandemic wave첫 번째 대유행 기간 동안 COVID-19 사례의 가정 접촉에서 경미한 COVID-19 환자의 조정된 타고난 및 T 세포 면역 반응Article Published on 2022-07-272022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] absence Alpha anti-N antibodies anti-RBD antibody B-cell cell-mediated response Concordance Contact COVID-19 COVID-19 case COVID-19 cases Cycle threshold value cytokine detectable early immune response early immune responses ELISA enrolled evaluated Factor Follow-up greater high accuracy household household contact household contacts IFN-α IFN-γ IL-1ra IL-1β IL-9 immune responses immunofluorescence Immunopathogenesis indirect immunofluorescence individual innate response interferon interferon-alpha Interferon-alpha (IFN-α) Interferon-gamma Interferon-gamma (IFN-γ) release assay (IGRA) IP-10 MCP-1 membrane mild COVID-19 patient MIP-1β moderate Nasopharyngeal swab Neutralizing antibodies nucleocapsid pandemic peptide peptide pools plasma plasma samples positive positive swab Proteins RANTES RBD reported response returned RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 swab screened Seroconversion serological serological response significant negative correlation Spike protein stimulated subject Surveillance Swab Swab test swabs T-cell T-cell immune response T-cell Response T-cell specific virus Whole blood whole blood. [DOI] 10.3389/fimmu.2022.920227 PMC 바로가기 [Article Type] Article
Identifying enhancers of innate immune signaling as broad-spectrum antivirals active against emerging viruses신종 바이러스에 대해 활성을 나타내는 광범위한 항바이러스제로서 타고난 면역 신호의 인핸서 식별Article Published on 2022-07-212022-09-11 Journal: Cell chemical biology [Category] COVID19(2023년), SARS, 치료제, [키워드] active against acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral activity boost broad-spectrum antiviral broad-spectrum antivirals Compound coronavirus Defense dependent on Drug screening emerging viruses enhancer Factors Gilteritinib identifying Immunity immunomodulatory molecules immunostimulatory IMPROVE increasingly Infection Innate innate immune innate immune activation Innate immunity innate response interferon interferon regulatory factor interferon regulatory factors. IRF7 IRFs Kinase inhibitor kinase inhibitors library nuclear translocation outbreak Pandemics pathogenic virus pathogenic viruses Pathogens proof proof of concept Regulatory RNA viruses SARS-CoV-2 screened severe acute respiratory syndrome Coronavirus Signaling viral infection virus [DOI] 10.1016/j.chembiol.2022.05.009 PMC 바로가기 [Article Type] Article
EWAS of post-COVID-19 patients shows methylation differences in the immune-response associated gene, IFI44L, three months after COVID-19 infectionObservational Study Published on 2022-07-072022-10-04 Journal: Scientific Reports [Category] 임상, 진단, 치료기술, 치료법, [키워드] analysis ANKRD9 cellular processes Control Corona COVID-19 COVID-19 case COVID-19 infection Degradation DNA methylation Epigenetic FDR IFI44L IMPDH2 implicated innate response interferon investigated involved lack limitation long-COVID Methylation Ontology pathophysiology pathway Patient performed Peripheral blood positive individuals post-COVID-19 patient Post-infection predict profile Prognosis prospective observational study Sample size severity significant difference significantly Support Systemic autoimmune diseases therapeutic target variety viral infection viruses [DOI] 10.1038/s41598-022-15467-1 PMC 바로가기 [Article Type] Observational Study
Serum Levels of Proinflammatory Lipid Mediators and Specialized Proresolving Molecules Are Increased in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 and Correlate With Markers of the Adaptive Immune Response중증 급성 호흡기 증후군 코로나바이러스 2 환자에서 전염증성 지질 매개체 및 전문 분해 분자의 혈청 수준이 증가하고 적응 면역 반응의 마커와 상관 관계가 있습니다Article Published on 2022-06-152022-09-11 Journal: The Journal of Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Anti-inflammatory Anti-nucleocapsid Anti-spike anti-spike antibody assays binding bioactive lipids Clinical outcome collected Concentration Control coronavirus coronavirus 2 died female hospital identify immune immune response Increased innate response Inpatient Level linoleic acid Lipid lipids male mediator molecule Omega pandemic pathogenic inflammation Pathways Patient patients positive correlation processed proinflammatory quantification Quantitative respiratory response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient SARS-CoV-2 patients serum Serum level serum levels severe acute respiratory syndrome Coronavirus Sex significantly higher significantly lower specialized proresolving molecules. symptomatic SARS-CoV-2 infection transition [DOI] 10.1093/infdis/jiab632 PMC 바로가기 [Article Type] Article
Reduced Antibodies and Innate Cytokine Changes in SARS-CoV-2 BNT162b2 mRNA Vaccinated Transplant Patients With Hematological Malignancies혈액암이 있는 SARS-CoV-2 BNT162b2 mRNA 백신 접종 이식 환자의 감소된 항체 및 선천적 사이토카인 변화Article Published on 2022-05-252022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] adaptive antibodies antibody approach Beta BNT162b2 mRNA vaccination Bone marrow booster vaccination CAR-T cell change Cohort cohorts correlated COVID-19 vaccination CXCL10 cytokine cytokine response Delta described develop Effectiveness Efficacy elicited healthy hematological hematological cancer Hematological malignancies Hematological malignancy heterogeneous high risk humoral Humoral response IFN-gamma IFN-γ IL-10 IL-15 IL-7 IL-8 individual Innate innate response IP-10/CXCL10 magnitude MIP-1α mRNA naïve neutralized offer omicron Patient patient cohort Predictive priming vaccination prognostic protection Proteins recipients reduced response SARS-CoV-2 SARS-CoV-2 BNT162b2 SARS-CoV-2 bnt162b2 mRNA vaccine SARS-COV-2 infection severe disease signature response significantly lower spike systemic cytokine response the patient the Spike Transplant transplantation. vaccination Vaccine WA1 wildtype Wuhan strain [DOI] 10.3389/fimmu.2022.899972 PMC 바로가기 [Article Type] Article
Efficacy and Safety of BCG Revaccination With M. bovis BCG Moscow to Prevent COVID-19 Infection in Health Care Workers: A Randomized Phase II Clinical TrialClinical Trial Published on 2022-03-222022-10-05 Journal: Frontiers in Immunology [Category] 임상, [키워드] Activation approved Bacillus BCG carried children clinical clinical trial COVID-19 COVID-19 pandemic cross cross protection Efficacy Efficacy and safety eight HCW HCWs Health care worker IgM and IgG immune response IMPROVE incidence of COVID-19 individual induce innate response Mycobacterium bovis NK cell NK cells phase PROTECT protocol randomized-controlled Randomly ranged reducing Registered respiratory infection revaccination Safe Safety statistical significance Symptoms symptoms of COVID-19 Symptoms. the WHO Tuberculosis Vaccine viral infections [DOI] 10.3389/fimmu.2022.841868 PMC 바로가기 [Article Type] Clinical Trial
Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine Research Published on 2022-03-142022-10-05 Journal: Nature Immunology [Category] 치료제, [키워드] adaptive analyzed antibody BNT162b2 BNT162b2 mRNA vaccine BNT162b2 vaccine CD8+ T cell cell death pathways circulating dependent on draining lymph node Efficacy IFN-γ immune responses Immunity immunization immunological mechanism inflammasome activation innate response interferon knockout mice MDA5 mice molecular mechanism natural killer cell necroptosis Pfizer-BioNTech pyroptosis response serum Signaling stimulate stimulated T cell response T cell responses Toll-like receptor type I underlie [DOI] 10.1038/s41590-022-01163-9 [Article Type] Research
Hypothesis: Emerging Roles for Aryl Hydrocarbon Receptor in Orchestrating CoV-2-Related Inflammation †Review Published on 2022-02-132022-10-31 Journal: Cells [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] ACE-2 adaptive angiotensin Apoptosis aryl Aryl hydrocarbon receptor AT1 binding boost build COVID-19 disease enzyme expression growth hydrocarbon IFN-I IL-6 immune tolerance Immunity Indolamine induce Inflammation Inflammatory Inflammatory response inflammatory state inhibitory innate response interferon Kynurenine limit management mechanism modulation Neutral pathogenic regulate respiratory Respiratory system role SARS-CoV-2 syndrome T cell target therapeutic target These data transporter Tryptophan type I [DOI] 10.3390/cells11040648 PMC 바로가기 [Article Type] Review